Research on vitamin B6 to treat children with autism began in the 1960s. British neurologists AF Heeley and GE Roberts, in their research, claimed that abnormal metabolites were detected in the urine of 11 of the 19 autistic children observed, after a tryptophan load test. A single 30mg vitamin B6 tablet normalized their urine. No behavioral studies, however, was conducted. Then, in 1968, German investigator VE Bonisch reported that 12 out of 16 autistic children studied, showed considerable improved behavior when administered a high dose of (100-600mg) vitamin B6. Three of his patients, in the open clinical trial, spoke for the first time after the medicine was given.
Latest clinical trials have revealed that 30-40% of autistic children showed significant improvement when vitamin B6 was administered to them. Some minor side effects, like sound sensitivity, irritability, and bed-wetting, cropped up. But they were quickly alleviated by administering additional magnesium.
Over the decades, children have shown a wide range of benefits from vitamin B6. These include, improved eye contact, more interest in the world around them, better speech, and fewer tantrums. They showed better overall improvement, though they weren’t completely cured of the ailment. Recent studies by US investigators at the University of North Carolina, Thomas Gualtieri et al, and by George Ellman et al, at California’s Sonoma State Hospital, have revealed positive effects of vitamin B6 on autistic children.
While no autistic person has been entirely cured after administering vitamin B6, several instances have been reported where there has been a remarkable improvement in the conditions. In an interesting case, an 18-year old autistic person was evicted from a leading mental home. Massive amounts of drugs had no effect on him. The guy was considered too much violent and even assaultive at times to be kept in a hospital. Psychiatrists and physicians then administered vitamin B6 and magnesium as the last resort. The person calmed down soon after a period of treatment. One of the psychiatrists in the team, later informed that she recently visited the man and his family, and was pleasantly surprised to find that he was now an easy going person who plays the guitar and sings songs.